41st Multicenter Airway Research Collaboration (MARC-41)
Design and Setting: This is a multicenter “before-after” study to investigate the feasibility and effectiveness of the hospital-initiated care bundle in adult patients hospitalized for asthma exacerbation. In this self-controlled cohort study, each participant’s rate of outcomes will be compared over a 3-year period (i.e., the 2 years before and 1 year after the implementation of the care bundle). The asthma care bundle will consist of several core elements across all participating sites and optional elements based on the available resources at each site. The core bundle elements are based on the national and international asthma guidelines, systematic literature review, and input from the multidisciplinary project team. The hospital-initiated care bundle will not differ from standard asthma care.MARC-41 will build on the success of the MARC-36 and -37 studies by implementing an evidenced-based hospital-initiated care bundle and evaluating its effectiveness at five geographically-diverse US sites. Site research staff will enroll participants from October 1, 2017 through September 30, 2018; each site will need to enroll 36 participants to meet the overall enrollment goal of 180 participants. All patients will be managed at the discretion of the treating physician
Study Population:Adults 18 to 54 years of age hospitalized for asthma exacerbation, with a history of asthma diagnoses and severe exacerbations before the index hospitalization, currently treated with inhaled corticosteroids, and the ability to give informed consent.
Study Period: 12 months; starting approximately October 1, 2017 and ending approximately September 30, 2018.